Summary

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• Gallium 68 PSMA-11 (Gallium Ga 68 PSMA-11) is indicated for positron emission tomography (PET) of prostate-specific membrane antigen-positive lesions in men with prostate cancer who are candidates for initial definitive therapy or have suspected recurrence based on elevated serum PSA level.
• The information stems from a total of 13 systematic reviews and meta-analyses, focusing on the diagnostic performance, safety, effectiveness, and specificity of Gallium Ga 68 PSMA-11 across various medical conditions including primary and secondary prostate cancer scenarios.
• In terms of diagnostic superiority in Prostate Cancer, Gallium Ga 68 PSMA-11 PET/CT showed high accuracy. It demonstrated superior sensitivity, positive predictive value, and accuracy compared to other imaging modalities when detecting bone metastases preoperatively.
• When comparing Gallium Ga 68 PSMA-11 with other tracers like F-labeled PSMA PET/CT tracers for prostate cancer detection, it exhibited similar or slightly higher sensitivity indicating strong diagnostic performance.
• Gallium Ga 68 PSMA-11 was found to be superior to traditional bone scintigraphy in detecting bone metastases, which further emphasizes its excellent diagnostic capabilities within the context of Prostate Cancer applications.
• In comparison with other radiotracers such as somatostatin analogs (SSAs), Gallium labeled agents were not impacted by SSAs treatment prior to imaging, especially while dealing with neuroendocrine tumors (NETs).
• The utility extends beyond NETs as well, where it shows higher sensitivity than FDG in detecting primary liver cancers suggesting that Gallium radiotracers may have specific advantages over traditional FDG imaging techniques.
• Gallium Ga 68 PSMA-11 has shown equal performance when used alongside biochemical recurrence detectors such as PET/MRI, highlighting its versatility across different imaging modalities.