Current best evidence on prescribed drugs

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Current best evidence on prescribed drugs

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Air polymer-type A

(ExEm Foam®)

ExEm Foam®

Drug updated on 12/11/2024

Dosage FormFoam (intrauterine; single dose kit: one syringe with 5 mL clear Gel [polymer type A–hydoxyethyl cellulose, glycerin and purified water], one syringe with 5 mL Sterile Purified Water and one Combifix® Adaptor [coupling device]
Drug ClassUltrasound contrast agents
Ongoing and
Completed Studies		ClinicalTrials.gov

Indication

  • Indicated for sonohysterosalpingography to assess fallopian tube patency in women with known or suspected infertility.

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Summary
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  • This summary is based on the review of two systematic review(s)/meta-analysis(es). [1-2]
  • For diagnosing tubal occlusion in women with infertility, 2D-HyCoSy had a sensitivity of 86% (95% confidence interval (CI) 80%-91%) and a specificity of 94% (95% CI 90%-96%), while 3D/4D-HyCoSy showed higher sensitivity at 95% (95% CI 89%-98%) but slightly lower specificity at 89% (95% CI 82%-94%).
  • There were no significant differences in diagnostic performance between the two methods, and no other drugs were compared in terms of effectiveness.
  • The overall frequency of severe pain perception during HyCoSy was 6% (95% CI 4-9), with no statistically significant differences based on the contrast used (Saline solution with air, EchoVist, SonoVue, ExEm-Foam).
  • No significant safety concerns or adverse effects specific to certain populations or subgroups were identified in the reviewed studies.
  • The studies focused on women undergoing HyCoSy for infertility assessment, with no significant differences in diagnostic accuracy or severe pain perception based on the type of contrast used.