Drug updated on 9/27/2024
| Dosage Form | Injection (subcutaneous; 250 mg/2 mL in a single-dose prefilled pen, 250 mg/2 mL in a single-dose prefilled syringe with needle shield) |
| Drug Class | interleukin-13 antagonists |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of adult and pediatric patients 12 years of age and older who weigh at least 40 kg with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. EBGLYSS can be used with or without topical corticosteroids.
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Summary
- This summary is based on the review of seven systematic review(s)/meta-analysis(es).
- Lebrikizumab demonstrated significant improvement in EASI75 at Week 16 with a risk ratio (RR) of 2.62 compared to placebo, with greater improvement in EASI (MD -20.37) and DLQI (MD -14.49) compared to placebo. [1-8]
- Among systemic treatments for atopic dermatitis, lebrikizumab 250 mg fortnightly showed the highest improvement in peak pruritus scores (LSM -64.90) but had similar short-term effectiveness to dupilumab.
- High-dose upadacitinib and abrocitinib had higher efficacy in EASI-50, EASI-75, and EASI-90 outcomes compared to lebrikizumab.
- Lebrikizumab was not significantly associated with serious adverse events (SAEs), non-serious adverse events (NSAEs), or mortality compared to placebo.
- There was an increased risk of conjunctivitis reported with lebrikizumab and tralokinumab.
- There is no population types or subgroups information available in the reviewed studies.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| EBGLYSS (lebrikizumab-lbkz) Prescribing Information. | 2024 | Eli Lilly and Company, Indianapolis, IN |