Summary

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• This summary is based on the review of two systematic review(s)/meta-analysis(es). ^[1-2]
• MP-AzeFlu (azelastine-fluticasone): Demonstrated the highest probability of moderate or large improvements in both Total Nasal Symptom Score and Rhinoconjunctivitis Quality-of-Life Questionnaire among patients with seasonal AR (allergic rhinitis), surpassing the effectiveness of fluticasone furoate and fluticasone propionate.
• Total Ocular Symptom Score: MP-AzeFlu showed the highest probability of moderate or large improvement in ocular symptoms.
• Comparison with other drugs: MP-AzeFlu provided faster and more sustained relief of nasal and ocular symptoms, showing superior efficacy over intranasal azelastine, fluticasone propionate alone, and combinations of intranasal corticosteroids with oral antihistamines for comprehensive AR symptom management.
• Long-term use of MP-AzeFlu was deemed safe with a favorable safety profile across age groups, including children, adults, and those aged 65 years or older; specific adverse effects or safety concerns were not detailed.
• No comparative safety data were provided between MP-AzeFlu and other medications or combinations.
• MP-AzeFlu (azelastine-fluticasone) was shown to be safe and effective for children, adults, and adults aged ≥65 years with seasonal or perennial AR, including those with moderate-to-severe disease, providing rapid, sustained symptom relief and quality-of-life improvements across these groups.