Avatrombopag

(Doptelet®)

Doptelet®

Drug updated on 11/16/2023

Dosage FormTablet (oral; 20 mg)
Drug ClassThrombopoietin receptor agonists
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • For the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure.
  • For the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.

Product Monograph / Prescribing Information

Document TitleYearSource
Doptelet (avatrombopag) Prescribing Information.2021AkaRx, Inc., Durham, NC

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Efficacy and safety of thrombopoietin receptor agonists in children and adults with persistent and chronic immune thrombocytopenia: a meta-analysis.2023Expert Opinion on Pharmacotherapy
Safety of non peptide thrombopoietin receptor agonists in patients with immune thrombocytopenia: A systematic review and meta analysis of short term double blind randomized clinical trials. 2023Experimental and Therapeutic Medicine
Risk of thrombotic events in immune thrombocytopenia patients treated with thrombopoietic agents: a systematic review and meta-analysis. 2023Thrombosis Journal
Use of thrombopoietin receptor agonists in adults with immune thrombocytopenia: a systematic review and Central European expert consensus. 2023Annals of Hematology
Efficacy and Incidence of Treatment-Related Adverse Events of Thrombopoietin Receptor Agonists in Adults with Immune Thrombocytopenia: A Systematic Review and Network Meta-Analysis of Randomized Controlled Study. 2023Acta Haematologica
Comparative efficacy of 19 drug therapies for patients with idiopathic thrombocytopenic purpura: a multiple-treatments network meta-analysis. 2022Annals of Hematology
Thrombopoietin receptor agonists for the treatment of primary immune thrombocytopenia: a meta-analysis and systematic review.2021Platelets
Efficacy and safety of avatrombopag in patients with chronic immune thrombocytopenia: a systematic literature review and network meta-analysis.2021Advances in Therapy
The efficacy and safety of thrombopoietin receptor agonists in patients with chronic liver disease undergoing elective procedures: a systematic review and meta-analysis.2021Platelets
Assessment report: Doptelet.2021EMA
Comparative Efficacy and Safety of Thrombopoietin Receptor Agonists in Adults With Thrombocytopenia: A Systematic Review and Network Meta-analysis of Randomized Controlled Trial. 2021Frontiers in Pharmacology
Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis.2020NIHR
Therapeutic options for adult patients with previously treated immune thrombocytopenia – a systematic review and network meta-analysis.2019Hematology
Assessment report: Doptelet.2019EMA
Efficacy and safety of avatrombopag in patients with thrombocytopenia: a systematic review and meta-analysis of randomized controlled trials.2019Frontiers in Pharmacology