Copper Cu 64 dotatate injection

(Detectnet®)

Detectnet®

Drug updated on 5/17/2024

Dosage FormInjection (intravenous; 148 MBq (4 mCi), [37 MBq 1 mCi /mL])
Drug ClassRadioactive diagnostic agents
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuro-endocrine tumors (NETs) in adults.

Latest News

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Summary
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  • Copper Cu 64 dotatate injection (Detectnet) is indicated for use with positron emission tomography (PET) for localization of somatostatin receptor-positive neuro-endocrine tumors (NETs) in adults.
  • Two studies from randomized controlled trials were reviewed to gather information about Detectnet's safety and effectiveness.
  • Both studies underline the safety of Detectnet, reporting no direct mention of adverse effects related to its usage. The second study explicitly states that no adverse events were related to Detectnet, indicating a high safety profile for diagnostic use in patients with somatostatin-receptor-positive NETs.
  • In terms of effectiveness, one study suggests Detectnet's effective imaging capability even beyond its primary indicated use, while the other confirms its effectiveness by reporting high diagnostic performance metrics including sensitivity and specificity rates as high as 100% and 96.8%, respectively.
  • The first study focuses on patients with type 2 diabetes, suggesting potential broader application possibilities for Detectnet beyond the immediate indication, whereas the second provides detailed information concerning diagnostic quality specifically in patients with somatostatin-receptor-positive NETs, highlighting its specificity and sensitivity within this population group.
  • Compared to other imaging agents mentioned in these studies, both position copper Cu 64 dotatate injection (Detectnet) favorably due to the absence of reported adverse events or serious conditions, along with exhibiting higher resolution images at an identified optimal dose, making it a highly effective tool over possibly lower-resolution or less-specific imaging alternatives.