Drug updated on 6/11/2024
Dosage Form | Tablet (oral; 100 mg, 200 mg) |
Drug Class | Hedgehog pathway inhibitors |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- To treat newly-diagnosed acute myeloid leukemia in combination with low-dose cytarabine, in patients ≥ 75 years of age or with comorbidities that preclude use of intensive induction chemotherapy in conjunction with low-dose cytarabine.
Latest News
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Summary
- Glasdegib (Daurismo) is indicated for the treatment of newly-diagnosed acute myeloid leukemia in combination with low-dose cytarabine, specifically targeting patients aged 75 years or older or those with comorbidities that prevent the use of intensive induction chemotherapy.
- Three studies were reviewed to gather information about this drug. These studies provided insights into various treatments for acute myeloid leukemia, focusing on populations similar to those targeted by Daurismo.
- The effectiveness and safety profiles of different therapies varied significantly. Targeted therapies combined with hypomethylating agents showed better overall survival rates but also had more adverse events compared to control groups.
- Hypomethylating agent and TKI combinations demonstrated promising results comparable to intensive chemotherapy combined with TKIs; however, specific data regarding their safety profile was not available.
- For older and medically unfit patients unsuitable for standard induction therapy, outcomes using hypomethylating agents or low-dose cytarabine showed moderate effectiveness but high mortality at 60 days (21%).
- While glasdegib's incorporation into new AML drugs was highlighted in one study discussing CML-MBP management parallels due to its clinical resemblance to AML, direct comparative efficacy and safety data between glasdegib and other agents were lacking across all three studies reviewed.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Daurismo (glasdegib) Prescribing Information. | 2023 | Pfizer Inc., New York, NY |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Therapies for acute myeloid leukemia in patients ineligible for standard induction chemotherapy: a systematic review. | 2023 | Future Oncology |
Management of chronic myeloid leukemia in myeloid blastic phase with novel therapies: a systematic literature review. | 2022 | Expert Review of Hematology |
Efficacy outcomes in the treatment of older or medically unfit patients with acute myeloid leukaemia: a systematic review and meta-analysis. | 2019 | Leukemia Research |