Summary

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• This summary is based on the review of one systematic review(s)/meta-analysis(es). ^[1]
• In patients with exocrine pancreatic insufficiency (EPI), including those with chronic pancreatitis, pancrelipase (Creon®) was associated with increased Coefficient of Fat Absorption (CFA) levels, showing an improvement range from a 7.5% increase in placebo recipients to a 36% increase in those treated with Creon®.
• Pancrelipase, including Creon®, also improved the Coefficient of Nitrogen Absorption (CNA) in EPI patients compared to placebo, with no significant differences in CNA-72h observed between Creon® (82.0% [SE: 1.2]) and Zenpep® (80.9% [SE: 1.2]) in a head-to-head study.
• Treatment with PERT generally led to increases in body weight (0.1 to 6.1 kg) and BMI or reduced their decline, benefiting EPI patients with weight loss or low BMI.
• Pancreatic enzyme replacement therapy (PERT), including Creon®, was generally reported as safe and well-tolerated across 18 studies, with no specific safety concerns or adverse effects highlighted for particular population types or subgroups.
• The systematic review focused on patients with exocrine pancreatic insufficiency (EPI) due to conditions like cystic fibrosis and chronic pancreatitis, finding that treatment with Creon® significantly improved the coefficient of fat absorption (CFA) and nitrogen absorption (CNA), as well as body weight and BMI, which is particularly relevant for EPI patients experiencing malabsorption and weight loss.