Summary

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• The COVID-19 Vaccine, mRNA (Comirnaty - Pfizer-BioNTech COVID-19 Vaccine) is indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals aged 12 years and older.
• A total of 82 systematic reviews/meta-analyses were reviewed to gather information about the safety, effectiveness, and subgroup considerations regarding the Comirnaty vaccine.
• The Comirnaty vaccine has shown a higher incidence of local and systemic reactions compared to other vaccines, like inactivated or protein subunit vaccines. However, serious adverse events were extremely rare across all types.
• Concerns specific to the Comirnaty vaccine include myocarditis among young males after the second dose. Despite these reports, most cases had a mild clinical course, with symptom resolution achieved quickly.
• Lymphadenopathy post-vaccination has been observed, particularly on the same side as the injection site, which can help avoid unnecessary interventions in oncology settings if recognized early enough.
• The effectiveness of the Comirnaty vaccine varies by dose but significantly enhances protection following two doses against symptomatic COVID–19 infection, along with hospitalization and death due to it.
• The Comirnaty vaccine's efficacy remains substantial even against variants such as Delta, especially after completion of the two-dose regimen.
• Pregnant women vaccinated with mRNA vaccines, including Comirnaty, displayed no clear harm from vaccination, suggesting protective benefits for both mother and fetus through strong maternal-fetal antibody responses elicited by vaccination.
• In cancer patients receiving immune checkpoint inhibitors (ICIs), there was no increase in the incidence of immune-related adverse events (irAEs). This suggests that mRNA vaccinations are safe for individuals undergoing cancer immunotherapy.
• Vaccine demonstrated notable effectiveness amongst adolescents and children, preventing them from getting infected while maintaining a reasonable safety profile; mild to moderate side effects are common, but serious ones are infrequent. Immunocompromised individuals showed variably reduced antibody responses to vaccination, highlighting the need for tailored vaccination and booster strategies.