Drug updated on 9/5/2024
Dosage Form | Injection (intraocular: 0.025%) |
Drug Class | Disclosing agents |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated to selectively stain the internal limiting membrane (ILM).
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Summary
- Tissueblue (brilliant blue g ophthalmic solution) is indicated to selectively stain the internal limiting membrane (ILM).
- This summary is based on the review of four systematic review(s)/meta-analysis(es). [1-4]
- IMH Closure Rate: BBG-assisted ILM peeling consistently achieved the highest postoperative macular hole (IMH) closure rates across studies, outperforming other dyes such as ICG, TA, and TB.
- Visual Acuity Improvement: BBG and the inverted ILM flap technique led to the most significant improvements in postoperative visual acuity (logMAR BCVA), with BBG showing superior outcomes compared to ICG and other adjuvants.
- Comparison with Other Drugs: BBG demonstrated greater effectiveness in both IMH closure rates and visual acuity improvement compared to ICG, TA, TB, and the absence of dye across studies.
- There is no safety information available in the reviewed studies.
- There is no population types or subgroups information available in the reviewed studies.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
TissueBlue (Brilliant Blue G Ophthalmic Solution) Prescribing Information. | 2019 | Dutch Ophthalmic USA, Exeter, NH |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Efficacy of different doses of dye-assisted internal limiting membrane peeling in idiopathic macular hole: a systematic review and network meta-analysis. | 2021 | International Journal of Ophthalmology |
Inverted ILM flap technique versus conventional ILM peeling for idiopathic large macular holes: a meta-analysis of randomized controlled trials. | 2020 | PLOS One |
Outcomes of 4 surgical adjuvants used for internal limiting membrane peeling in macular hole surgery: a systematic review and network Meta-analysis. | 2020 | International Journal of Ophthalmology |
Internal limiting membrane peeling with different dyes in the surgery of idiopathic macular hole: a systematic review of literature and network meta-analysis. | 2019 | International Journal of Ophthalmology |