Sugammadex

(Bridion®)

Bridion®

Drug updated on 11/9/2023

Dosage FormInjection (intravenous; 200 mg/2 mL, 500 mg/5 mL)
Drug ClassMultiple
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults and pediatric patients aged 2 years and older undergoing surgery.

Product Monograph / Prescribing Information

Document TitleYearSource
Bridion (sugammadex) Prescribing Information.2022Merck Sharp & Dohme LLC Rahway, NJ

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Sugammadex for reversing neuromuscular blockages after lung surgery: A systematic review and meta-analysis2023Journal of clinical medicine
Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis2023Heliyon
Should rocuronium and sugammadex replace succinylcholine for airway emergencies in class B ambulatory anesthesia settings?2023Minerva anestesiologica
Superiority of sugammadex in preventing postoperative pulmonary complications2023Chinese medical journal
The effect of sugammadex versus neostigmine on postoperative nausea and vomiting: a meta-analysis of randomized controlled trials with trial sequential analysis2023Current drug safety
Reversal of neuromuscular block with sugammadex compared with neostigmine and postoperative pulmonary complications in obese patients: meta-analysis and trial sequential analysis2023British journal of anaesthesia
Sugammadex Reduced the Incidence of Postoperative Pulmonary Complications in Susceptible Patients Identified by ARISCAT Risk Index: Systematic Review and Meta-analysis2023Advances in therapy
Appropriate dosing of sugammadex for reversal of rocuronium-/vecuronium-induced muscle relaxation in morbidly obese patients: a meta-analysis of randomized controlled trials.2022Journal of International Medical Research
Sugammadex-induced anaphylactic reaction: A systematic review.2022Journal of Aneasthsiology Clinical Pharmacology
Sugammadex compared with neostigmine in reducing postoperative pulmonary complications in older patients: a meta-analysis2022British journal of anaesthesia
Sugammadex in Colorectal Surgery: A Systematic Review and Meta-analysis2022The Journal of surgical research
Sugammadex in systemic mastocytosis : Case report and a systematic review of literature2022Die Anaesthesiologie
Sugammadex in awakening from general anesthesia: systematic review and meta-analysis2022Revista da Associacao Medica Brasileira
Efficacy and safety of sugammadex for neuromuscular blockade reversal in pediatric patients: an updated meta-analysis of randomized controlled trials with trial sequential analysis2022BMC pediatrics
Efficacy and safety of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in patients with end-stage renal disease: a systematic review and meta-analysis. 2021Medicina
The effect of dexamethasone on sugammadex reversal of rocuronium-induced neuromuscular blockade in surgical patients undergoing general anesthesia.2021Medicine
The effect of sugammadex on prothrombin and activated partial thromboplastin time. 2021Cureus
Postoperative pulmonary complications after sugammadex reversal of neuromuscular blockade: a systematic review and meta-analysis with trial sequential analysis2021Anesthesia, essays and researches
Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials2021Perioperative medicine
Epidemiology and outcomes of residual neuromuscular blockade: A systematic review of observational studies2020Journal of clinical anesthesia
Sugammadex for reversing neuromuscular blockages after lung surgery: A systematic review and meta-analysis2020Data in brief
Data and meta-analysis for choosing sugammadex or neostigmine for routine reversal of rocuronium block in adult patients2020Data in brief
Role of sugammadex in accelerating postoperative discharge: An updated meta-analysis2020Journal of clinical anesthesia
Incidence of residual neuromuscular blockade and use of neuromuscular blocking agents with or without antagonists: A systematic review and meta-analysis of randomized controlled trials2020Journal of clinical anesthesia
Use of sugammadex in patients with neuromuscular disorders: a systematic review of case reports2019BMC anesthesiology
The comparative efficacy and safety of sugammadex and neostigmine in reversing neuromuscular blockade in adults. A Cochrane systematic review with meta-analysis and trial sequential analysis.2018Anaesthesia
Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: a systematic review2018BMC anesthesiology

Clinical Practice Guidelines