Summary

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• Ibrexafungerp (Brexafemme) has demonstrated a superior clinical cure ratio and mycological eradication rate compared to fluconazole/placebo, particularly in cases where the condition is advanced or potentially resistant to first-line treatments.
• Three studies were reviewed, providing information on the safety and effectiveness of ibrexafungerp for treating vulvovaginal candidiasis (VVC).
• Ibrexafungerp was found significantly effective against VVC caused by C. albicans, highlighting its efficacy against this common pathogen.
• Compared to other antifungals like fluconazole, ibrexafungerp showed similar efficacy but with potential advantages due to increased resistance and limited coverage of non-Candida albicans species by fluconazole.
• Adverse events related to ibrexafungerp were mainly gastrointestinal symptoms, including nausea and diarrhea; however, it remains a well-tolerated option for VVC based on data reviewed.
• While current data focus largely on adult and post-menarchal pediatric females, indicating broad application for treatment within these groups, there is an emphasized need for additional studies assessing long-term safety and efficacy in special populations, suggesting further research is needed.