Summary

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• This summary is based on the review of nine systematic review(s)/meta-analysis(es). ^[1-9]
• Complement inhibitors (Eculizumab, Ravulizumab, Pegcetacoplan) significantly reduced LDH (Lactate Dehydrogenase) levels (-1462.0 U/L for ≤26 weeks and -1696.5 U/L for >26 weeks) and increased hemoglobin levels (1.4 g/dL and 1.9 g/dL) in patients with paroxysmal nocturnal hemoglobinuria (PNH), with at least 50% of patients avoiding transfusions.
• In atypical hemolytic uremic syndrome (aHUS), Eculizumab and Ravulizumab demonstrated comparable efficacy, with Ravulizumab preferred due to lower cost and less frequent dosing, while Eculizumab in renal transplant patients significantly reduced recurrence (OR = 0.05), dialysis need (OR = 0.13), and rejection (OR = 0.09).
• Pegcetacoplan effectively increased hemoglobin levels and reduced transfusion requirements in patients with PNH, with minimal adverse events reported.
• In studies on paroxysmal nocturnal hemoglobinuria (PNH) with complement inhibitors, no deaths were reported, and few adverse events occurred in pegcetacoplan-treated patients. Serious adverse events were noted in 42% of patients in atypical hemolytic uremic syndrome (aHUS) studies, with two cases of meningococcal infection reported in eculizumab-treated patients.
• Eculizumab in renal transplant patients with aHUS showed improved renal outcomes, including reduced need for dialysis, without specific safety concerns mentioned.
• There is no population type or subgroup information available in the reviewed studies.