Summary

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• Delafloxacin (Baxdela) is indicated for the treatment of adults with acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP), caused by designated susceptible bacteria.
• Three studies were reviewed, which collectively analyzed data from multiple randomized controlled trials to compare delafloxacin's safety and effectiveness against other antibiotic agents in treating ABSSSI and CABP.
• In terms of clinical efficacy, delafloxacin exhibited a comparable cure rate to comparator antibiotics such as linezolid, tigecycline, and vancomycin. For MRSA-associated ABSSSIs specifically, it showed similar clinical cure rates, underscoring its potential value in treating these challenging infections.
• The analysis revealed no significant difference between delafloxacin's safety profile and comparative antibiotics. However, it was associated with a higher incidence of diarrhea but lower incidence of nervous system disorders, suggesting specific patient subgroups might benefit more from this drug.
• Even though explicit mentions about population subgroups were limited within the studies; adult patients suffering from acute bacterial infections, particularly those at risk for or suffering from MRSA-associated infections, could potentially benefit most effectively from this drug.
• Compared to other drugs like linezolid and tigecycline used in the treatment of ABSSSI, delafloxacin demonstrated non-inferiority and even showed superiority over vancomycin, making it an essential consideration due to its better tolerability highlighted by lower discontinuation rates due to adverse events.