Bevacizumab

(Avastin®)

Avastin®

Drug updated on 12/11/2024

Dosage FormInjection (intravenous; 100 mg/4 mL [25 mg/mL] or 400 mg/16 mL [25 mg/mL])
Drug ClassVascular endothelial growth factor (VEGF) inhibitors
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of metastatic colorectal cancer, in combination with intravenous fluorouracil based chemotherapy for first- or second-line treatment
  • Indicated for the treatment of metastatic colorectal cancer, in combination with fluoropyrimidineirinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for second-line treatment in patients who have progressed on a first-line bevacizumab product-containing regimen
  • Indicated for the treatment of unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer, in combination with carboplatin and paclitaxel for first-line treatment
  • Indicated for the treatment of recurrent glioblastoma in adults
  • Indicated for the treatment of metastatic renal cell carcinoma in combination with interferon alfa
  • Indicated for the treatment of persistent, recurrent, or metastatic cervical cancer, in combination with paclitaxel and cisplatin, or paclitaxel and topotecan
  • Indicated for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer: in combination with carboplatin and paclitaxel, followed by Avastin as a single agent, for stage III or IV disease following initial surgical resection
  • Indicated for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer: in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan for platinum-resistant recurrent disease who received no more than 2 prior chemotherapy regimens
  • Indicated for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer: in combination with carboplatin and paclitaxel or carboplatin and gemcitabine, followed by Avastin as a single agent, for platinum-sensitive recurrent disease
  • Indicated for the treatment of hepatocellular Carcinoma (HCC): in combination with atezolizumab for the treatment of patients with unresectable or metastatic HCC who have not received prior systemic therapy.

Latest News

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Summary
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  • This summary is based on the review of 127 systematic review(s)/meta-analysis(es). [1-126]
  • In meningioma patients, the mean progression-free survival (PFS) and overall survival (OS) were 19.1 ± 4.7 months and 23.9 ± 8.4 months, respectively, with six-month, twelve-month, and twenty-four-month PFS rates at 0.80, 0.66, and 0.25, and OS rates at 0.89, 0.86, and 0.48, respectively; the response rate was 0.33 (95% confidence interval (CI): 0.14–0.60).
  • In hepatocellular carcinoma (HCC), sorafenib combined with bevacizumab showed improved outcomes in Asian populations compared to other therapies, such as lenvatinib or atezolizumab with bevacizumab, following initial treatment with sorafenib.
  • For non-small cell lung cancer (NSCLC), the combination of pemetrexed with bevacizumab was associated with improved overall survival (hazard ratio (HR) = 0.87) and PFS (HR = 0.63), although there was an increase in grade ≥3 adverse events with the combination.
  • In epithelial ovarian cancer, combining bevacizumab with carboplatin and paclitaxel significantly improved PFS (HR: 0.73; 95% CI: 0.58, 0.92; p = 0.008) compared to carboplatin and paclitaxel alone.
  • In HCC, common adverse events with treatments including bevacizumab were hypertension, non-central nervous system (CNS) bleeding, thromboembolic events, gastrointestinal perforation, pain, and proteinuria.
  • For epithelial ovarian cancer, bevacizumab combined with carboplatin and paclitaxel resulted in a higher incidence of adverse events, notably hypertension, non-CNS bleeding, thromboembolic events, gastrointestinal perforation, pain, and proteinuria, compared to chemotherapy alone.
  • In NSCLC, the combination of bevacizumab and pemetrexed led to an increase in grade ≥3 adverse events with an odds ratio of 2.15, indicating higher toxicity compared to pemetrexed monotherapy.
  • In colorectal cancer, bevacizumab combined with chemotherapy was associated with an increase in grade ≥3 adverse events, including hypertension and gastrointestinal perforation, compared to monotherapy.
  • In meningioma patients, bevacizumab showed high efficacy in refractory, high-grade, or neurofibromatosis-associated cases, with the study population consisting of 47.9% male patients.
  • In HCC, sorafenib combined with bevacizumab yielded better outcomes in Asian populations, and in NSCLC, the combination of lenvatinib with programmed cell death protein 1 (PD-1) and locoregional therapy (LRT) demonstrated higher conversion to surgery rates and increased objective response rates in certain subgroups.

Product Monograph / Prescribing Information

Document TitleYearSource
Avastin (bevacizumab) Prescribing Information.2022Genentech, Inc., South San Francisco, CA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Phase I-IV Drug Trials on Hepatocellular Carcinoma in Asian Populations: A Systematic Review of Ten Years of Studies2024International Journal of Molecular Sciences
Application of bevacizumab in the management of meningiomas: a systematic review and meta-analysis2024Neurosurgical Review
Correction: The effectiveness and safety of bevacizumab versus cetuximab in the treatment of colorectal cancer: a systematic review and meta‑analysis2024International Journal of Clinical Pharmacy
Evaluation of bevacizumab biosimilar on wound healing complications in patients with colorectal cancer undergoing endoscopic mucosal resection: A systematic review and meta-analysis in anorectal medicine2024International Wound Journal
Effectiveness of bevacizumab in the treatment of metastatic colorectal cancer: a systematic review and meta-analysis2024Bmc Gastroenterology
Comparison of osimertinib plus bevacizumab against osimertinib alone in NSCLC harboring EGFR mutations: a systematic review and meta-analysis2024Therapeutic Advances in Medical Oncology
Efficacy and Safety of Trifluridine/Tipiracil-Containing Combinations in Colorectal Cancer and Other Advanced Solid Tumors: A Systematic Review2024The Oncologist
A Network Meta-analysis of the Efficacy of Drug Therapy in First-line Treatment of Advanced Hepatocellular Carcinoma2024Journal of Gastrointestinal and Liver Diseases : Jgld
Efficacy and safety of PARP inhibitors combined with antiangiogenic agents in the maintenance treatment of ovarian cancer: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials2024Frontiers in Pharmacology
Comparative analysis of bevacizumab and LITT for treating radiation necrosis in previously radiated CNS neoplasms: a systematic review and meta-analysis2024Journal of Neuro-oncology
The emerging therapies are reshaping the first-line treatment for advanced hepatocellular carcinoma: a systematic review and network meta-analysis2024Therapeutic Advances in Gastroenterology
The efficacy of adjunctive mitomycin C and/or anti-VEGF agents on glaucoma tube shunt drainage device surgeries: a systematic review2024Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von
Bevacizumab is associated with a higher gastrointestinal/genitourinary fistula or perforation risk in cervical cancer patients undergoing pelvic radiotherapy2024International Journal of Gynaecology and Obstetrics: the Official Organ of the
A Systematic Review and Meta-Analysis on the Effectiveness of Radiotherapy and Temozolomide Treatment With or Without Bevacizumab in Patients With Glioblastoma Multiforme2024Neurology India
Optimizing Outcomes: Bevacizumab with Carboplatin and Paclitaxel in 5110 Ovarian Cancer Patients-A Systematic Review and Meta-Analysis2024Pharmaceuticals (basel, Switzerland)
Systemic conversion therapies for initially unresectable hepatocellular carcinoma: a systematic review and meta-analysis2024Bmc Cancer
Combination of pemetrexed with bevacizumab for non-small-cell lung cancer: a meta-analysis study2024Journal of Cardiothoracic Surgery
Comparison of systemic treatments for previously treated patients with unresectable colorectal liver metastases: a systematic review and network meta-analysis2024Frontiers in Oncology
Cost-effectiveness of immune checkpoint inhibitors as a first-line therapy for advanced hepatocellular carcinoma: a systematic review2024Health Economics Review
Impact of bevacizumab on clinical outcomes and its comparison with standard chemotherapy in metastatic colorectal cancer patients: a systematic review and meta-analysis2024Journal of Pharmaceutical Policy and Practice
Trifluridine-tipiracil plus bevacizumab versus trifluridine-tipiracil monotherapy for chemorefractory metastatic colorectal cancer: a systematic review and meta-analysis2024Bmc Cancer
Safety and Efficacy of Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma and Impaired Liver Function: A Systematic Review and Meta-Analysis2024Liver Cancer
Chordoma Genetic Aberrations and Targeted Therapies Panorama: A Systematic Literature Review2024Journal of Clinical Medicine
Safety of first-line systemic therapy in patients with metastatic colorectal cancer: a network meta-analysis of randomized controlled trials2024Bmc Cancer
Identification of cardiotoxicity related to non-small cell lung cancer (NSCLC) treatments: A systematic review2023Frontiers in Pharmacology
Clinical efficacy and safety of atezolizumab plus bevacizumab versus lenvatinib in the treatment of advanced hepatocellular carcinoma: A systematic review and meta-analysis2023Medicine
Different doses of bevacizumab in combination with chemotherapy for advanced colorectal cancer: a meta-analysis and Bayesian analysis2023International Journal of Colorectal Disease
Angiogenesis inhibitors for the treatment of epithelial ovarian cancer2023The Cochrane Database of Systematic Reviews
Treatment options for recurrent platinum-resistant ovarian cancer: A systematic review and Bayesian network meta-analysis based on RCTs2023Frontiers in Oncology
Identifying optimal first-line immune checkpoint inhibitors based regiments for advanced non-small cell lung cancer without oncogenic driver mutations: A systematic review and network meta-analysis2023Plos One
Comparing efficacy and safety of first-line treatment of metastatic renal cell carcinoma: A Bayesian network meta-regression analysis2023Frontiers in Oncology
First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Systematic Review and Patient-Level Network Meta-Analysis2023Liver Cancer
Adverse events of bevacizumab for triple negative breast cancer and HER-2 negative metastatic breast cancer: A meta-analysis2023Frontiers in Pharmacology
Molecular targeted therapy and immunotherapy in advanced hepatocellular carcinoma: a systematic review and Bayesian network meta-analysis based on randomized controlled trials2023Annals of Medicine
Immune-Based Combinations versus Sorafenib as First-Line Treatment for Advanced Hepatocellular Carcinoma: A Meta-Analysis2023Current Oncology (toronto, Ont.)
Comparison of the efficacy and safety of first-line treatments for of advanced EGFR mutation-positive non-small-cell lung cancer in Asian populations: a systematic review and network meta-analysis2023Frontiers in Pharmacology
Comparative efficacy and safety of systemic therapy for advanced hepatocellular carcinoma: a systematic review and network meta-analysis2023Frontiers in Oncology
Risks of hypertension and thromboembolism in patients receiving bevacizumab with chemotherapy for colorectal cancer: A systematic review and meta-analysis2023Cancer Medicine
Atezolizumab in Combination with Bevacizumab for the Management of Patients with Hepatocellular Carcinoma in the First-Line Setting: Systematic Literature Review and Meta-Analysis2023Liver Cancer
Proteasome inhibitors in the treatment of nonsmall cell lung cancer: A systematic review of clinical evidence2023Health Science Reports
Comparison of the profiles of first-line PD-1/PD-L1 inhibitors for advanced NSCLC lacking driver gene mutations: a systematic review and Bayesian network meta-analysis2023Therapeutic Advances in Chronic Disease
Comparison of the efficacy and safety of third-line treatments for metastatic colorectal cancer: a systematic review and network meta-analysis2023Frontiers in Oncology
Atezolizumab plus bevacizumab versus lenvatinib as first-line therapy for advanced hepatocellular carcinoma: A systematic review and meta-analysis2023Clinical and Experimental Hepatology
Bevacizumab Treatment for Low-Grade Serous Ovarian Cancer: A Systematic Review2023Current Oncology (toronto, Ont.)
Effectiveness and safety of atezolizumab-bevacizumab in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis2023Eclinicalmedicine
Bevacizumab plus erlotinib versus erlotinib alone for advanced EGFR-mutant non-small cell lung cancer: a meta-analysis of randomized clinical trials2023European Journal of Medical Research
Efficacy and safety of atezolizumab plus bevacizumab treatment for advanced hepatocellular carcinoma in the real world: a single-arm meta-analysis2023Bmc Cancer
The Utilization of Bevacizumab in Patients with Advanced Ovarian Cancer: A Systematic Review of the Mechanisms and Effects2022International Journal of Molecular Sciences
Comparison of efficacy and safety of bevacizumab biosimilar and original bevacizumab in non-squamous non-small cell lung cancer: a systematic review and meta-analysis2022Translational Cancer Research
Cost-Effectiveness Analysis of Five Systemic Treatments for Unresectable Hepatocellular Carcinoma in China: An Economic Evaluation Based on Network Meta-Analysis2022Frontiers in Public Health
Bevacizumab versus PARP-inhibitors in women with newly diagnosed ovarian cancer: a network meta-analysis2022Bmc Cancer
Combined Immunotherapy with Chemotherapy versus Bevacizumab with Chemotherapy in First-Line Treatment of Driver-Gene-Negative Non-Squamous Non-Small Cell Lung Cancer: An Updated Systematic Review and Network Meta-Analysis2022Journal of Clinical Medicine
Systemic Treatments for Advanced Small Bowel Adenocarcinoma: A Systematic Review2022Cancers
Clinical trials targeting neurofibromatoses-associated tumors: a systematic review2022Neuro-oncology Advances
A comprehensive systematic review and network meta-analysis: the role of anti-angiogenic agents in advanced epithelial ovarian cancer2022Scientific Reports
Tolerability on Serious Adverse Events of First-Line Bevacizumab and Cetuximab for RAS Wild-Type Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis2022Healthcare (basel, Switzerland)
Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in women with epithelial ovarian cancer2022The Cochrane Database of Systematic Reviews
Cost-effectiveness of pembrolizumab for the first-line treatment of patients with unresectable or metastatic MSI-H/dMMR colorectal cancer in the United States2022Journal of Medical Economics
Risk and Incidence of Infection with Bevacizumab in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis2022Oncology Research and Treatment
Efficacy and Safety of Immunotherapy for Cervical Cancer-A Systematic Review of Clinical Trials2022Cancers
Objective Response Predicts Survival in Advanced Hepatocellular Carcinoma Treated with Systemic Therapies2022Clinical Cancer Research : an Official Journal of the American Association for
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline2022Journal of Clinical Oncology : Official Journal of the American Society of
Efficacy and safety of bevacizumab combined with EGFR-TKIs in advanced non-small cell lung cancer: A meta-analysis2022Thoracic Cancer
The efficacy and toxicity of maintenance therapy with bevacizumab plus pemetrexed versus bevacizumab/pemetrexed alone for stage IIIB/IV nonsquamous non-small cell lung cancer: A meta-analysis of randomized controlled trials2022Journal of Clinical Pharmacy and Therapeutics
Efficacy and Safety of Bevacizumab in Pretreated Metastatic Breast Cancer: A Systematic Review and Meta-Analysis2022Oncology Research and Treatment
Immunotherapy or targeted therapy as the first-line strategies for unresectable hepatocellular carcinoma: A network meta-analysis and cost-effectiveness analysis2022Frontiers in Immunology
Comparison of the efficacy and safety in the treatment strategies between chemotherapy combined with antiangiogenic and with immune checkpoint inhibitors in advanced non-small cell lung cancer patients with negative PD-L1 expression: A network meta-analysis2022Frontiers in Oncology
Efficacy and safety of metronomic chemotherapy in maintenance therapy for metastatic colorectal cancer: A systematic review of randomized controlled trials2022Medicine
A systematic review and network meta-analysis of first-line immune checkpoint inhibitor combination therapies in patients with advanced non-squamous non-small cell lung cancer2022Frontiers in Immunology
Efficacy and safety of adding bevacizumab biosimilar or original drug to platinum-based chemotherapy as first-line treatment in patients with advanced NSCLC: a systematic review and meta-analysis2022Therapeutic Advances in Medical Oncology
First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review2022Current Oncology (toronto, Ont.)
Bevacizumab-Induced Hypertension as a Potential Physiological Clinical Biomarker for Improved Outcomes in Patients With Recurrent Glioblastoma Multiforme: A Systematic Review2022Cureus
Treatment patterns for advanced non-small cell lung cancer in the US: A systematic review of observational studies2022Cancer Treatment and Research Communications
Efficacy and safety evaluations of anlotinib in patients with advanced non-small cell lung cancer treated with bevacizumab2022Frontiers in Pharmacology
Efficacy and Safety of Epidermal Growth Factor Receptor (EGFR)-Tyrosine Kinase Inhibitor Combination Therapy as First-Line Treatment for Patients with Advanced EGFR-Mutated, Non-Small Cell Lung Cancer: A Systematic Review and Bayesian Network Meta-Analysis2022Cancers
A systematic review on intra-arterial cerebral infusions of chemotherapeutics in the treatment of glioblastoma multiforme: The state-of-the-art2022Frontiers in Oncology
Efficacy and Safety of Bevacizumab Biosimilars Compared With Reference Biologics in Advanced Non-small Cell Lung Cancer or Metastatic Colorectal Cancer Patients: A Network Meta-Analysis2022Frontiers in Pharmacology
Overall Survival Benefits of First-Line Treatments for Asian Patients with Advanced Epidermal Growth Factor Receptor-Mutated NSCLC Harboring Exon 19 Deletion: A Systematic Review and Network Meta-Analysis2022Cancers
Safety Assessment on Serious Adverse Events of Targeted Therapeutic Agents Prescribed for RAS Wild-Type Metastatic Colorectal Cancer: Systematic Review and Network Meta-Analysis2022International Journal of Environmental Research and Public Health
Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-small-cell lung cancer: a systematic review and meta-analysis of randomised controlled trials2022Bmj Open
Atezolizumab plus bevacizumab versus nivolumab as first-line treatment for advanced or unresectable hepatocellular carcinoma: A cost-effectiveness analysis2022Cancer
Efficacy and safety of PARP inhibitors in elderly patients with advanced ovarian cancer: a systematic review and meta-analysis2022International Journal of Gynecological Cancer : Official Journal of the
Multiple Bayesian network meta-analyses to establish therapeutic algorithms for metastatic triple negative breast cancer2022Cancer Treatment Reviews
Efficacy and safety of monotherapy and combination therapy of immune checkpoint inhibitors as first-line treatment for unresectable hepatocellular carcinoma: a systematic review, meta-analysis and network meta-analysis2022Discover Oncology
A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials2021Cancers
Molecular and clinical predictors of improvement in progression-free survival with maintenance PARP inhibitor therapy in women with platinum-sensitive, recurrent ovarian cancer: A meta-analysis2021Cancer
Clinical option of pemetrexed-based versus paclitaxel-based first-line chemotherapeutic regimens in combination with bevacizumab for advanced non-squamous non-small-cell lung cancer and optimal maintenance therapy: evidence from a meta-analysis of randomized control trials2021Bmc Cancer
Optimal Therapies for Recurrent Glioblastoma: A Bayesian Network Meta-Analysis2021Frontiers in Oncology
Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group2021Journal of Gynecologic Oncology
Radiotherapy versus combination radiotherapy-bevacizumab for the treatment of recurrent high-grade glioma: a systematic review2021Acta Neurochirurgica
Comparison of Efficacy of Systemic Therapies in Advanced Hepatocellular Carcinoma: Updated Systematic Review and Frequentist Network Meta-Analysis of Randomized Controlled Trials2021Journal of Hepatocellular Carcinoma
Efficacy and Safety Associated With Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma: A Meta-analysis2021Jama Network Open
Vascular endothelial growth factor (VEGF) targeting therapy for persistent, recurrent, or metastatic cervical cancer2021The Cochrane Database of Systematic Reviews
Treatment of Advanced Gastro-Entero-Pancreatic Neuro-Endocrine Tumors: A Systematic Review and Network Meta-Analysis of Phase III Randomized Controlled Trials2021Cancers
The Role of Immunotherapy in Hepatocellular Carcinoma: A Systematic Review and Pooled Analysis of 2,402 Patients2021The Oncologist
Optimizing Survival and the Changing Landscape of Targeted Therapy for Intermediate and Advanced Hepatocellular Carcinoma: A Systematic Review2021Journal of the National Cancer Institute
First-Line Systemic Treatment Strategies for Unresectable Hepatocellular Carcinoma: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials2021Frontiers in Oncology
Selection of first-line systemic therapies for advanced hepatocellular carcinoma: A network meta-analysis of randomized controlled trials2021World Journal of Gastroenterology
Atezolizumab plus bevacizumab versus sorafenib or atezolizumab alone for unresectable hepatocellular carcinoma: A systematic review2021World Journal of Gastrointestinal Oncology
Incidence and Risk of Hypertension in Cancer Patients Treated With Atezolizumab and Bevacizumab: A Systematic Review and Meta-Analysis2021Frontiers in Oncology
Non-surgical management of advanced hepatocellular carcinoma: A systematic review by Cancer Care Ontario2021Canadian Liver Journal
Meta-analysis of risk factors associated with oxaliplatin hypersensitivity reactions in cancer patients2021International Journal of Clinical Oncology
Risk of Thrombo-Embolic Events in Ovarian Cancer: Does Bevacizumab Tilt the Scale? A Systematic Review and Meta-Analysis2021Cancers
Treatment options for progression or recurrence of glioblastoma: a network meta-analysis2021The Cochrane Database of Systematic Reviews
Network Meta-analysis of First-Line Systemic Treatment for Patients With Metastatic Colorectal Cancer2021Cancer Control : Journal of the Moffitt Cancer Center
Maintenance treatment of combination with bevacizumab vs single agent for advanced non-squamous non-small cell lung cancer: A systematic review and meta-analysis2021Medicine
Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer2021The Cochrane Database of Systematic Reviews
Selection of optimal first-line immuno-related therapy based on specific pathological characteristics for patients with advanced driver-gene wild-type non-small cell lung cancer: a systematic review and network meta-analysis2021Therapeutic Advances in Medical Oncology
Evidence-Based Management of Hepatocellular Carcinoma: Systematic Review and Meta-analysis of Randomized Controlled Trials (2002-2020)2021Gastroenterology
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope?2021Frontiers in Oncology
The Safety and Effectiveness of Bevacizumab in the Treatment of Nonsquamous Non-Small-Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials2021Biomed Research International
The efficacy and safety of bevacizumab combined with FOLFOX regimen in the treatment of advanced colorectal cancer: A systematic review and meta-analysis2021Medicine
Effectiveness and Safety of Adding Bevacizumab to Platinum-Based Chemotherapy as First-Line Treatment for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis2021Frontiers in Medicine
Systematic Review on Infusion Reactions to and Infusion Rate of Monoclonal Antibodies Used in Cancer Treatment2020Anticancer Research
Effectiveness of Lomustine Combined With Bevacizumab in Glioblastoma: A Meta-Analysis2020Frontiers in Neurology
Is there an efficacy-effectiveness gap between randomized controlled trials and real-world studies in colorectal cancer: a systematic review and meta-analysis2020Translational Cancer Research
Efficacy and safety of nanoparticle-albumin-bound paclitaxel compared with solvent-based taxanes for metastatic breast cancer: A meta-analysis2020Scientific Reports
Chemotherapy plus bevacizumab as an optimal first-line therapeutic treatment for patients with right-sided metastatic colon cancer: a meta-analysis of first-line clinical trials2020Esmo Open
Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis2020The Cochrane Database of Systematic Reviews
Bevacizumab or PARP-Inhibitors Maintenance Therapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis2020International Journal of Molecular Sciences
Radiological Recurrence Patterns after Bevacizumab Treatment of Recurrent High-Grade Glioma: A Systematic Review and Meta-Analysis2020Korean Journal of Radiology
Meta-analysis on the risk of fatal adverse events by bevacizumab, cetuximab, and panitumumab in 31 randomized trials including 25,000 patients with colorectal carcinoma2020Medicine
Efficacy and safety of therapies for EGFR-mutant non-small cell lung cancer with brain metastasis: an evidence-based Bayesian network pooled study of multivariable survival analyses2020Aging
Efficacy and Safety of Epidermal Growth Factor Receptor (EGFR) Inhibitors Plus Antiangiogenic Agents as First-Line Treatments for Patients With Advanced EGFR-Mutated Non-small Cell Lung Cancer: A Meta-Analysis2020Frontiers in Oncology
Bevacizumab improves survival in metastatic colorectal cancer patients with primary tumor resection: A meta-analysis2019Scientific Reports
Progression-Free but No Overall Survival Benefit for Adult Patients with Bevacizumab Therapy for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis2019Cancers

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