Segesterone acetate and ethinyl estradiol

(Annovera®)

Annovera®

Drug updated on 12/11/2024

Dosage FormVaginal ring (intravaginal; 103 mg segesterone acetate and 17.4 mg ethinyl estradiol)
Drug ClassProgestin/estrogen CHCs
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for use by females of reproductive potential to prevent pregnancy.

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Summary
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  • This summary is based on the review of one systematic review/meta-analysis. [1]
  • High general satisfaction with NuvaRing® was reported by 80-90% of users, with ease of use improving over time across all settings.
  • Mixed results were observed for continuation of use, indicating variability in long-term adherence to NuvaRing® among users.
  • Sexual satisfaction outcomes were less consistently reported, with mixed results across studies regarding its impact on sexual satisfaction.
  • There is no safety information available in the reviewed studies, aside from noting that ring-related events were associated with discontinuation of the contraceptive vaginal ring (CVR).
  • The majority of studies on NuvaRing® were conducted in high-income settings, but no specific information is provided regarding population types or subgroups, such as age or comorbid conditions.

Product Monograph / Prescribing Information

Document TitleYearSource
Annovera (segesterone acetate and ethinyl estradiol) Prescribing Information.2022TherapeuticsMD, Inc., Boca Raton, FL

Systematic Reviews / Meta-Analyses

Clinical Practice Guidelines